Neurodegenerative diseases

With the ketogenic diet, new ground is opening up in treatment of this group of illnesses which have such a significant socio-economic impact on our society and on individuals, including conditions such as Parkinson's, Alzheimer'sor amyotrophic lateral sclerosis( ALS). However the findings are still preliminary and limited to animal models for the moment (other than a few exceptions), but they seem to demonstrate that use of a ketogenic diet can slow down cognitive decay. The mechanisms hypothesised are generally a neuroprotective effect from low levels of blood glucose, an action which improves functioning of the mitocondria (cellular organelles charged with energy production), which malfunctions in some of these conditions, and, in some conditions, the high degree of fat in the diet.


Essential bibliography:

Beckett TL, Studzinski CM, Keller JN, Paul Murphy M, Niedowicz DM. A ketogenic diet improves motor performance but does not affect beta-amyloid levels in a mouse model of Alzheimer's disease. Brain Res. Apr 10 2013;1505:61-67.

Hashim SA, Vanitallie TB. Ketone Body Therapy: From ketogenic diet to oral administration of ketone ester. J Lipid Res. Mar 20 2014.

Paoli A, Bianco A, Damiani E, Bosco G. Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases. Biomed Res Int. 2014;2014:474296.

Siva N. Can ketogenic diet slow progression of ALS? Lancet neurology. 2006;5(6):476.

Yang X, Cheng B. Neuroprotective and Anti-inflammatory Activities of Ketogenic Diet on MPTP-induced Neurotoxicity. Journal of molecular neuroscience : MN. 2010.

Yao J, Brinton RD. Targeting mitochondrial bioenergetics for Alzheimer's prevention and treatment. Current pharmaceutical design. 2011;17(31):3474-3479.


Interview with Dr. Raffaele Pilla


Share by: